Generation Scotland: Scottish Family Health Study (GS:SFHS) is a comprehensive, family-based cohort study aimed at understanding the genetic basis of common complex diseases and treatment responses. Conducted between 2006 and 2011, it recruited over 24,000 participants, most of whom consented to record linkage and recontact. Participants provided blood or saliva samples for DNA extraction, genotyping, and biochemistry, as well as urine samples. In 2015, extensive genotyping was performed on DNA from over 20,000 participants using high-density genome-wide chip genotyping, Illumina OmniExpress SNP GWAS, and exome chips. The study ensured data quality through rigorous QC analyses, verifying sample identity, and assessing population stratification using principal component analysis. The genetic data is used in various research projects, including cognition studies at the University of Edinburgh and collaborations with the CHARGE consortium. Methylation data is also available for a subset of 19,500 samples. The study's findings contribute to international consortia and local research efforts, enhancing the understanding of genetic influences on health.

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