Born in Bradford’s Better Start (BiBBS) is an innovative experimental birth cohort that will simultaneously evaluate the impact of multiple early life interventions using efficient study designs. Better Start Bradford (BSB) has been allocated £49 million from the Big Lottery Fund to implement 22 interventions to improve outcomes for children aged 0–3 in three deprived and ethnically diverse inner-city areas of Bradford. BiBBS aims to evaluate the effects of these interventions on social and emotional development, communication and language development, and nutrition and obesity by following families from pregnancy into childhood and using linkage to routinely collected data.