The NURTuRE project was devised to create a national kidney biobank as recommended in the UK Renal Research Strategy 2016. Strategic Aims: To work towards achieving this NURTuRE will: 1. Create a national Kidney Bio Bank for collection and storage of biological samples from 3,000 CKD patients and up > 800 NS patients, to provide a strategic resource for fundamental and translational research. 2. Develop and implement proactive UK protocol driven cohort studies in CKD and NS to investigate determinants of and risk factors for clinically important adverse outcomes. 3. Engage patient cohorts, with consent to approach for any future research study. NURTuRE Objectives: 1. The provision of comprehensive clinical and laboratory data from cohort studies. 2. The provision of high quality bio-samples with centralised storage/retrieval. 3. To carry out core biomarker analysis of biopsy specimens in biofluids of all patients recruited and parallel assessment. 4. Follow-up specimen collection. First patient recruitment - By 31 June 2017 CKD - baseline and 100 % follow up collections '“ over 2 years NS: baseline and 20% follow up - over 3 years. Healthy Volunteers - baseline