The comparison between two pivotal instruments like the Strengths and Difficulties Questionnaire (SDQ) and the Quick Inventory of Depressive Symptomatology (QIDS-16) is a crucial challenge faced by researchers. Given the crucial role these questionnaires play in the field of mental health research, understanding the correlation and consistency between items in SDQ and QIDS-16 forms a significant part of the analyzing process. Harmony, a powerful tool developed specifically to address this need, uses advanced natural language processing and AI models to simplify this process for researchers. With Harmony’s cutting-edge technology, it’s possible to compare each item of SDQ vs QIDS-16 and receive a percentage match between the items. An efficient aspect of Harmony is its ability to use large language models to do the comparison, which makes it powerful just not for SDQ and QIDS-16, but also for other instruments. These findings can immensely aid psychologists in their research and enable them to understand the correlation and areas of overlap in behaviours and symptoms that these questionnaires assess. Harmony isn’t just an efficient tool, it’s a user-friendly platform that simplifies the researcher’s task. Choosing between stored datasets or uploading your own in PDF format through its web interface at https://harmonydata.ac.uk/app enables researchers to draw comparisons from multiple facets. To conclude, if you’re evaluating the SDQ vs QIDS-16, using Harmony is not only a smart choice but also a highly productive one. Its multi-lingual support makes it a go-to tool for global research collaboration.