For researchers and psychologists working with survey data, comparing items from different questionnaires is a common, yet challenging, aspect of the analysis. When it comes to the Strengths and Difficulties Questionnaire (SDQ) versus the European School Survey Project on Alcohol and Drugs (ESPAD) comparison, the task can be quite daunting. The SDQ, which focuses on behavioural and emotional aspects of children, differs greatly from ESPAD which looks at adolescent drug and alcohol usage. With the SDQ vs ESPAD comparison, psychologists are inclined to harmonise these varying items to draw accurate, comparable conclusions. Harmony, a software tailored to fulfill this purpose, is capable of simplifying this harmonisation using natural language processing and generative AI models. It enables researchers to easily measure the percentage match between each item present in SDQ and ESPAD, thereby contributing to an easier SDQ vs ESPAD analysis. The user-friendly interface of Harmony allows researchers to choose from the database or directly upload their own questionnaire in PDF format. Plus, Harmony’s power of comparison extends beyond English, as it aptly handles a variety of languages. Harmony not only manages the complex SDQ vs ESPAD comparison, but also helps researchers utilise cohort and longitudinal studies effectively by permitting within and across study comparisons. This can help discover potential variations in findings that could arise from the impact of different social conditions. The process of harmonisation no longer has to be a laborious task. By using Harmony in SDQ vs ESPAD comparisons, researchers can turn this time-consuming process into an efficient and effective one.