Harmony, a powerful software tool for psychologists, provides an efficient solution for comparing different questionnaires, such as PHQ-9 and PGSI. Using advanced natural language processing and generative AI models, Harmony makes it possible to identify similarities and differences in distinct questionnaires, thus adding value to the harmonisation process. This comparative review focuses on the nuances of using Harmony for the PHQ-9 vs PGSI analysis. Harmony performs an in-depth analysis by giving a percentage match between each item in PHQ-9 and PGSI. This way, researchers are able to compare and correlate specific aspects of depression as per the PHQ-9 questionnaire with problem gambling metrics from the PGSI tool. Making such a PHQ-9 vs PGSI comparison can offer valuable insights for integrating mental health and addictive behaviour studies. The PHQ-9 vs PGSI comparison through Harmony is not only seamless but also customizable. Researchers can upload their own versions of these instruments, or use those available in Harmony’s database. With the ability to even handle multi-language comparisons, Harmony stands as an invaluable resource for researchers dealing with PHQ-9 vs PGSI studies. It simplifies the process and enhances the accuracy, thereby contributing to a more holistic understanding of mental health parameters.