Comparing the General Health Questionnaire (GHQ-12) and the Drug Abuse Screening Test (DAST) in traditional ways can be time-consuming and burdensome. However, psychologists and researchers can now simplify this process by using Harmony, an innovative software developed for harmonisation of questionnaire items. The GHQ 12 vs DAST comparison becomes efficient and less subjective with Harmony’s natural language processing and generative AI models. Harmony can compare every item in GHQ-12 and DAST, quantify the likeness between them, and even provide a percentage match. This facilitates a faster and more comprehensive comparison, aiding researchers in answering critical questions surrounding psychological distress and drug abuse. Using Harmony to compare GHQ 12 vs DAST is simple: researchers just need to select the instruments from the software’s database or upload the PDF forms of these instruments on the Harmony’s web interface. Harmony’s multilingual feature is an added benefit in the GHQ 12 vs DAST comparison, allowing researchers to harmonise the questionnaire items across different languages and hence provide a global perspective. Furthermore, by using Harmony, psychologists can repeat the same longitudinal analysis across different studies for GHQ 12 and DAST, enabling them to test the consistency of the results. Therefore, for a precise and efficient comparison of GHQ 12 vs DAST, Harmony is undoubtedly an exceptional tool.