Psychologists and researchers often find themselves needing to compare the General Health Questionnaire (GHQ 12) with the Alcohol, Smoking, and Substance Involvement Screening Test - Substance Use (ASSIST). The challenge lies in the time- consuming and subjective process of harmonisation, which is why we suggest using the Harmony software. Harmony is an AI-powered tool that utilizes large language models to effectively compare these two instruments, providing a percentage match for each item. The terms ‘GHQ 12 vs ASSIST’ can be quickly matched, enabling easier and more efficient analysis for researchers. In addition to comparing ‘GHQ 12 vs ASSIST’, Harmony brings versatility to the table, as it is designed to consistently analyse multiple studies, assisting researchers in testing whether results vary across different studies. The tool offers a user-friendly interface where researchers can either select instruments from their database or upload their own in PDF format. More importantly, Harmony has the capacity to compare items in multiple languages — a significant advantage for multicultural and international studies. The GHQ 12 vs ASSIST comparison is vital for understanding differences in psychological distress and substance use identification. Using Harmony, researchers can optimize their time and bring more objectivity to their work. If you are a psychologist or researcher looking to harmonise the GHQ 12 and ASSIST questionnaires, consider using Harmony to streamline the process and boost your productivity.