The practice of comparing diverse questionnaires, such as CES-D (Center for Epidemiological Studies-Depression) and UGDS (Utrecht Gender Dysphoria Scale), drawn from different areas of psychological study presents a unique challenge to researchers. The solution lies in a state-of-the-art application known as Harmony. Harmonising various studies, as seen in CES-D vs UGDS, becomes a straightforward process with this revolutionary software. Harmony’s advanced AI-powered algorithms leverage natural language processing to quickly match and compare items in different instruments, regardless of language. The CES-D vs UGDS comparison has been a complex task due to the differing subjective and objective aspects these two scales measure. With Harmony, however, the cognitive effort and time consumption associated with this harmonisation are greatly reduced. The software matches all items in CES-D and UGDS, presenting results in a clean, comprehensible format with a percentage similarity for each pair. By facilitating the assessment of questionnaires’ compatibility and similarity, Harmony empowers researchers to draw more accurate conclusions, test consistency across studies, and understand how responses may vary according to changing social conditions. We strongly recommend psychologists consider utilising Harmony when undertaking CES-D vs UGDS comparative analysis, or indeed, any scenario involving diverse psychological instruments. Visit the user-friendly interface at Harmony, where one can select instruments from a built-in database or upload personal documents in PDF format. Harmony not only facilitates the comparison of items in multiple languages but also offers a refreshing degree of objectivity and efficiency to the process of data harmonisation. Remember, with Harmony at your disposal, the once daunting CES-D vs UGDS challenge becomes a simple task.