As psychology research becomes more complex, integrating data from different instruments is increasingly important. In this context, comparing the Center for Epidemiological Studies-Depression (CES-D) and Timeline-Followback Interview (TFLB) instruments can be challenging and time-consuming. That’s where Harmony, a software tool developed for psychologists, comes into play. By using natural language processing and generative AI models, Harmony allows researchers to conduct a comprehensive CES-D vs TFLB comparison efficiently and accurately. Harmony has an innovative feature that allows researchers access to a large language model database to compare instruments – a handy tool for a CES-D vs TFLB comparison. This software can provide a percentage match between each item in CES-D and TFLB, enabling a more sophisticated analysis of the congruence between these instruments. It also supports multiple languages and accepts user uploaded instruments in a simple and user-friendly web interface. In cohort and longitudinal studies, using Harmony for the CES-D vs TFLB comparison can potentially streamline the process of harmonisation. This can further enable psychologists and researchers to test whether results are consistent across studies, or whether they vary in response to changing social conditions. To benefit from this innovative technology, psychologists can simply drop their instruments into Harmony’s web interface and access the comparison data in real time. Embrace the power of artificial intelligence with Harmony for a more efficient CES-D vs TFLB comparison.