Software The disciplines of psychology and social sciences often necessitate the comparison and harmonisation of different questionnaires. This task can be quite cumbersome and time-consuming. In recent times, the need to compare CES-D and SPOVI-14 questionnaires was identified. To facilitate this, we present Harmony, a software tool specifically designed to aid in such comparisons, thereby simplifying the harmonisation process. CES-D vs SPOVI-14 comparison can be easily and efficiently done using Harmony’s AI-powered technology. Harmony utilizes natural language processing and generative AI models which efficiently increases productivity by enabling researchers to harmonise questionnaire items, even those in different languages. In the context of CES-D vs SPOVI-14, Harmony leverages these large language models to compare instruments and present a percentage match between each item in these questionnaires. This innovative approach to questionnaire comparison provides a reliable, less subjective, and much quicker solution to traditional manual methods. It is strongly suggested for researchers examining the CES-D vs SPOVI-14 questionnaires to try out the Harmony software. Harmony’s intuitive interface allows users to select instruments from its own database or manually load their own instruments in PDF form into the web interface. It can even execute comparisons in multiple languages. The CES-D vs SPOVI-14 analysis potential afforded by Harmony introduces a new era of facilitated research studies progression and is a must-try for psychology and social science researchers.