Software Psychologists and researchers often face the complex task of harmonising parameters and items in various research questionnaires. Two such popular questionnaires are the Center for Epidemiological Studies-Depression (CES-D) and the Hypomania Checklist (HCL-16), which psychologists frequently use for assessing mental health. Harmony, designed to simplify the harmonisation process, provides an intuitive solution to compare and contrast CES-D vs HCL-16 efficiently. The CES-D vs HCL-16 comparison for their content, structure, and usability using Harmony will undoubtedly enhance the studies’ precision and understanding. Harmony uses state-of-the-art natural language processing and generative AI techniques, which enable it to match and compare questionnaire items, even if they’re in different languages. By using the Harmony software, researchers directly compare each item in CES-D vs HCL-16, obtaining a percentage match between them. This software greatly optimizes the process and reduces the subjectivity and time consumption traditional methods often involve. We encourage all psychologists to leverage Harmony for their questionnaire analysis. Not only can you select from the inbuilt CES-D and HCL-16 instruments within Harmony’s database, but also you have the flexibility to incorporate your own custom tools. Utilizing Harmony’s web interface, CES-D vs HCL-16 analysis becomes streamlined and efficient, leading to improved research outcomes. Visit https://harmonydata.ac.uk/app today to experience the ease of comparing CES-D vs HCL-16 with Harmony’s innovative technology.