The comparative analysis of two significant tools in psychology research, CES-D (Center for Epidemiological Studies-Depression) and FTND (Fagerstrom Test for Nicotine Dependence), is crucial in understanding overlapping and distinct implications. Harmonising the items in CES-D vs FTND using the innovative software ‘Harmony’ significantly simplifies this process. The CES-D helps evaluate depressive symptoms, while the FTND assesses nicotine dependence. Harmony, using its advanced language models, allows for a comprehensive comparison between the two instruments and aids in identifying percentage matches between each item. The mundane task of going through extensive questionnaires to harmonise items has been revolutionised with the introduction of Harmony. The CES-D vs FTND comparison can be executed efficiently using this tool. You can select the CES-D and FTND directly from Harmony’s database or upload these instruments in PDF format on the tool’s user-friendly web interface. This powerful software empowers researchers to utilise cohort and longitudinal studies to their maximum extent, enabling within and across study comparisons with ease. Harmony’s efficient comparison of CES-D vs FTND is not only limited to a single language but also supports multiple languages. Using advanced AI algorithms, the tool can power through large volumes of data, making the obscure process of harmonisation efficient and objective. As psychologists or social scientists, integrating Harmony into your research process will notably enhance the effectiveness and speed of your comparative analysis tasks such as CES-D vs FTND. Therefore, Harmony unquestionably offers the potential to be an invaluable tool in the world of psychology research.