Comparative analysis of different psychological and clinical tools like “Center for Epidemiological Studies-Depression” (CES-D) and “Edinburgh Study of Youth Transitions and Crime” (ESYTC) can prove to be extremely beneficial in comprehensive research and study. However, doing it manually can be highly time-consuming and subject to human errors. This is where Harmony can prove to be a game changer. It employs extensive language models and natural language processing techniques, providing an objective percentage match for individual items within CES-D and ESYTC, which can efficiently streamline the process of comparative analysis. In comparing CES-D vs ESYTC, an understanding of their contexts is essential. CES-D focuses on symptoms associated with depression, whereas ESYTC encompasses a range of behaviours related to youth transitions and crime. Given these distinct themes, one might initially assume minimal correlation between the two. However, using Harmony to compare CES-D vs ESYTC can provide insightful connections that might reflect the interplay between factors of mental health and delinquent behaviours, particularly in young adults. In an increasingly data-driven research space, efficient tools such as Harmony make the task of harmonisation of questionnaire items significantly more accessible. Harnessing its potential to compare CES-D vs ESYTC will provide clinicians and psychologists leverage to implement cohesive measures to address mental health and behavioural issues with advanced accuracy and precision. The versatility of Harmony to compare items in different languages further widens its utility for researchers across the globe. Therefore, we strongly recommend psychologists to explore and utilize this cutting-edge tool in their research practices.