Comparison of psychological instruments such as CES-D (The Center for Epidemiological Studies–Depression Scale) and DTC (Drinking to Cope) can be a daunting task for researchers. Instead of the traditional manual method of harmonisation, using Harmony, an innovative tool that employs natural language processing and generative AI models, can ease this process. Harmony can provide a percentage match between each item in CES-D and DTC, thereby facilitating an easier comparison of the two instruments and offering a streamlined process for CES-D vs DTC analysis. Harmony revolutionizes the process of comparing instruments like CES-D and DTC with its ability to pore through extensive databases, and even user-uploaded PDFs of instruments. This is crucial when taking into account the detailed structure of each instrument: CES-D’s comprehensive 20-item questionnaire designed to gauge symptoms associated with depression, versus DTC’s targeted approach to understanding alcohol utilization as a coping mechanism. The term CES-D vs DTC takes on a new meaning with Harmony, as it brings harmony to the process of understanding the link between depression and coping strategies involving alcohol use. Finally, it should be emphasized that Harmony’s application in CES-D vs DTC comparison goes far beyond the convenience of the tool itself. Harmony allows researchers the ability to execute repeated longitudinal analysis across a variety of studies, testing for consistent results or discrepancies based on changing social conditions. Moreover, this tool is designed to handle multilingual analysis, expanding the scope of your research outreach. Leverage the power of Harmony for your CES-D vs DTC comparisons to enrich your analysis and advance the field of psychological and social science research.