The ongoing study of health and mental wellness often involves comparing different questionnaires such as the CES-D (Center for Epidemiological Studies-Depression) and CRISIS (CoRonavIruS Health Impact Survey). Looking into these comparisons leads us to the term “CES-D vs CRISIS,” which represents a comparative analysis of these instruments. CES-D, developed in 1977, effectively measures depressive symptoms, aiding in the identification of individuals at risk for clinical depression. CRISIS, on the other hand, gauges the psychological stress and impacts related to the pandemic. For psychologists and social scientists, comparing such health and mental wellness instruments manually is time-consuming and subjective. The term “CES-D vs CRISIS” calls into mind the massive effort such manual harmonisation could take. However, the Harmony software offers an innovative solution to this issue. It utilizes natural language processing and AI models to assist researchers in harmonising items across different questionnaires, even if they are in multiple languages. In the continued exploration of “CES-D vs CRISIS,” using Harmony can provide a more efficient and objective harmonisation. In the context of the CES-D vs CRISIS comparison, it provides a percentage match of each item, enabling a more seamless comparison between the two. Overall, conducting a CES-D vs CRISIS comparison becomes significantly less stressful and more effective when utilising Harmony.