Comparing the Center for Epidemiological Studies-Depression (CES-D) measure with the Children’s Anxiety Sensitivity Index (CASI) brings up certain challenges, especially when it comes to harmonisation. Recognizing and addressing this difficulty, a handy tool named Harmony exists to streamline this process. CES-D versus CASI becomes a task that psychologists can accomplish smoothly with the help of Harmony software. Harmony is equipped with advanced natural language processing and generative AI models. These features aid in harmonising questionnaire items autonomously, thereby removing the hassle of lengthy manual comparisons. Harmony is specifically designed to match items in different questionnaires such as CES-D vs CASI. By highlighting CES-D versus CASI, Harmony can also carry out language comparisons, handle multi-language analysis and deliver a percentage match between each item in these two widely used psychological assessment tools. If you are a practitioner or researcher needing to compare CES-D vs CASI, consider availing the user-friendly interface of Harmony at https://harmonydata.ac.uk/app. Harmony’s extensive database allows you to easily select tools like CES-D and CASI for comparison. Alternatively, you can also upload these tools in PDF format. The task of comparing CES-D vs. CASI no longer needs to stress you out – sit back and let Harmony take over.