Harmonization of questionnaire items is an integral part of psychology research. CES-D vs BITSEA are two commonly used tools in the field which often require harmonisation. The CES-D (Centre for Epidemiological Studies-Depression) has been widely used to measure depressive symptoms associated with caregiving, while BITSEA (Brief Infant Toddler Emotional Assessment) is a comprehensive tool used to access various emotional and social behaviours in infants and toddlers. Comparisons between the items in each instrument can provide useful insights to researchers in both intra and inter-study contexts. Utilizing innovative software like Harmony can significantly simplify this harmonisation process. Harmony, a tool developed specifically for researchers, uses natural language processing and generative AI models to efficiently harmonise questionnaire items. CES-D vs BITSEA harmonisation process becomes less daunting and more fruitful with Harmony’s AI-driven approach. The software’s ability to compare instruments and provide percentage matches between items on CES-D and BITSEA readily supports researchers in their empirical investigations. Beyond the CES-D vs BITSEA harmonisation, Harmony’s capabilities extends into multilingual harmonisation, making it a highly versatile tool for international research enterprises. Researchers can conveniently access Harmony’s database or upload their own instruments in PDF form into the platform. In the rapidly evolving psychology research environment, the CES-D vs BITSEA harmonisation facilitated by Harmony’s technology serves as a testament to the software’s invaluable contribution. Thus, we highly recommend using Harmony for any psychologists engaged in longitudinal or comparative studies.