Comparison and harmonisation of psychological questionnaires are vital processes for research, and the need for an efficient tool cannot be overstated. Harmony, a cutting-edge tool designed for psychologists and social scientists, is a perfect fit for comparing widely used instruments like CES-D and ARBQ. Harmony uses natural language processing and generative AI models to compare the question items in these instruments accurately, making the process less subjective and time-consuming. As a case in point, when comparing the Center for Epidemiological Studies-Depression (CES-D) scale and the Anxiety-Related Behaviours Questionnaire (ARBQ), one can appreciate Harmony’s utility. These instruments, although measuring distinct psychological constructs, display overlap in several areas that Harmony can accurately match and highlight. Thus, the CES-D vs ARBQ comparison, usually a daunting task due to the high number of item variables, becomes seamless with Harmony’s AI-based harmonisation process. Experts looking to conduct a CES-D vs ARBQ analysis can easily make use of Harmony by selecting the instruments directly from the software’s vast database or uploading their copies in PDF format. The web interface is user-friendly and capable of comparing items in multiple languages. Notably, CES-D vs ARBQ, with their broad applicability to diverse populations and scenarios, highlights Harmony’s potential to transform questionnaire harmonisation significantly.