The comparison process between Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) and History & Aetiology Schedule (HAS) can be made seamless with the innovative use of the Harmony software. Harmony, with its ability to draw comparisons between different instruments using language models, can make the complex and time-consuming process of harmonisation efficient and effortless. The debate of ASSIST vs HAS can thus, be addressed objectively without bias. In the context of ASSIST vs HAS, which covers a wide range of questionnaire statements like drug use by injection (ASSIST) and a comprehensive list pertaining to living conditions, history of the present illness, past medical history, life events, etc. (HAS), Harmony provides an in-depth, multi-layered analysis. By giving a percentage match between individual items from ASSIST and HAS, the software allows psychologists to interpret disparities or similarities in a much more streamlined manner. ASSIST vs HAS is a vital cross-comparison for researchers and psychologists who aim to make effective interpretations from complex longitudinal and cohort studies. Leveraging Harmony for this purpose not only enhances the quality of the comparisons but also simplifies the process on a large scale. Additionally, the software’s multilingual comparison feature can help make ASSIST vs HAS analysis more accessible to a broader range of researchers worldwide. So, to efficiently and accurately carry out your ASSIST vs HAS comparisons, make the smart choice by choosing Harmony.